By car from the North (Bologna, Pisa or Florence airports)
Autostrada or Motorway del Sole (A1) 
Exit Valdichiana, direction Perugia
The E45 direction Perugia /Roma
Exit Marsciano- Collepepe

From the South and Fiumicino or Ciampino airports at Rome:

Follow the GRA and Uscita 10 A1 (Florence)
Leave the A1 at Orte and follow E45 Perugia
Exit Marsciano-Collepepe

From both directions after leaving the E45 go towards Marsciano and you pass a Metano petrol station on the right. Take the next road on the right. There’s a small fruit stall on the corner as you make this turn. This road takes you through a small village. Take the fourth road on the right. Stay on this road until you reach a T-junction with a block of red brick apartments on the right. Turn right onto a gravel road and after a couple of minutes you will see Sant’Orsola on your left, a large pale yellow house surrounded by trees.